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Introduction: Organizations can manage knowledge inside and create organizational learning mechanisms to integrate Knowledge Management (KM) at their core of strategic policies.
Objective: This research was conducted to identify and prioritize influential factors on the effective performance of KM in a specialized cardiovascular on-call hospital.
Materials and Methods: The methodology of this study was cross-sectional analytical. The statistical population included all personnel with Bauchler (BSc) and higher degrees in a specialty cardiovascular hospital in Karaj City, Iran (N=452). The data collection tool was a researcher-made 38-item questionnaire. The reliability of the research tool was estimated as 0.97 using the Cronbach α coefficient. The exploratory and confirmatory factor analyses were performed to analyze the obtained data.
Results: Based on the findings, 64.2% of the participants were females 48.37% had Bauchler degree. Five major factors were identified in the adequate performance of KM in hospitals, and they explained 76.21% of the general variance. Among these variables, technological and cultural factors (0.94) had the most and human factor (0.41) the least regressive weight. The knowledge management situation was lower than the mean score of the questionnaire (P=0.01, Mean±SD= 2.52±1.08). 
Conclusion: Organizational culture and technology are more important than other factors to establish KM. Therefore, maintaining and strengthening the cultural components affecting KM and establishing the necessary information technology should be the priorities of universities of medical sciences.

Keywords: Knowledge management, Cardiology service, Hospital

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