Introduction: It is estimated that over ‎‏70%‏‎ of pregnant women experience nausea and vomiting ‎during the first trimester of pregnancy. Pregnancy is associated with intense physical changes in the ‎ability to perform usual roles that may have an adverse effect on quality of life (QOL).

‎ Objective: The aim of this study is to clarify the characteristics of nausea and vomiting in pregnancy ‎and to determine the relationship between nausea and vomiting of pregnancy and quality of life in ‎various weeks of pregnancy.‎

Methods: This study is a cross-sectional research that was carried out in three governmental ‎hospitals. Demographic variables and health related quality of life for nausea and vomiting ‎questionnaire were used. Rohdes index was used to determine the severity of nausea and vomiting.‎

Results: According to the findings, an increase in gestational age was correlated with decreasing of ‎nausea and vomiting in pregnancy (NVP). The overall scores of NVP at ‎‏4-7‏‎ weeks was significantly ‎higher than at ‎‏16-19‏‎ and ‎‏20-22‏‎ weeks (P<‎‏0.0001‏‎). The physical scores of quality of life were ‎significantly correlated with the overall scores of NVP and nausea and vomiting at ‎‏4-7‏‎, ‎‏12-15‏‎ and ‎‏16-19‏‎ weeks. There was a significant relationship between the severity of vomiting and decreasing ‎quality of life at all weeks in all gestational weeks.‎

Conclusion: Nausea and vomiting in pregnancy can especially decrease the quality of life during ‎pregnancy, specially in physical domain.‎