Sun, Apr 28, 2024
Volume 32, Issue 3 (6-2022)
JHNM 2022, 32(3): 196-202 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khammar M, Ghorashi Z, Manshoori A. Comparing the Effects of Paracetamol and Pethidine on First-stage Labor Pain Relief and Their Maternal and Neonatal Complications. JHNM 2022; 32 (3) :196-202
URL: http://hnmj.gums.ac.ir/article-1-1903-en.html
URL: http://hnmj.gums.ac.ir/article-1-1903-en.html
1- Midwifery (MSc), Departments of Midwifery, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Assistant Professor, Departments of Midwifery, School of Nursing and Midwifery, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , zghorashi@yahoo.com
3- Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran..
2- Assistant Professor, Departments of Midwifery, School of Nursing and Midwifery, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , zghorashi@yahoo.com
3- Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran..
Abstract: (700 Views)
Introduction: The pain relief effect of Paracetamol, as a safe analgesic drug in labor, compared to Pethidine, as a well-known analgesic drug, need to be more evaluated.
Objective: This study aims to compare the effects of Paracetamol and Pethidine on the first-stage labor pain relief and neonatal and maternal complications.
Materials and Methods: This single-blind, parallel group, randomized clinical trial conducted on 100 nulliparous pregnant women referred to a maternity hospital in Rafsanjan Iran in 2018 who were selected using a convenience sampling method and by assigned into two groups Paracetamol (n=49, receiving 100 mg intravenous Paracetamol) and Pethidine (n= 51, receiving 50 mg intravenous Pethidine) using the minimization method. The drugs were administered when there was at least a 4-cm cervical dilation. Maternal complications and infant’s 1 and 5-min the Apgar scores and ability to breastfeed were evaluated. Pain intensity measured by the Visual Analogue Scale (VAS) and compared using two-way repeated measures ANOVA before and 30 minutes, 1, 2, 3 and 4 hours after drug administration.
Results: There were no significant differences between the two groups in term of age, body mass index, and gestational age, and no significant difference in pain intensity in any groups among the time points. Maternal complications were significantly lower in the Paracetamol group than in the Pethidine group; however, the difference was statistically significant only in terms of nausea (P=0.04). Infants’ breastfeeding ability was significantly better in Paracetamol group than in the Pethidine group (P=0.04). The results of two-way ANOVA showed that the mean VAS score was not significantly different between the two groups.
Conclusion: Paracetamol can alleviate the first-stage labor pain similar to Pethidine, but with fewer maternal and neonatal complications.
Objective: This study aims to compare the effects of Paracetamol and Pethidine on the first-stage labor pain relief and neonatal and maternal complications.
Materials and Methods: This single-blind, parallel group, randomized clinical trial conducted on 100 nulliparous pregnant women referred to a maternity hospital in Rafsanjan Iran in 2018 who were selected using a convenience sampling method and by assigned into two groups Paracetamol (n=49, receiving 100 mg intravenous Paracetamol) and Pethidine (n= 51, receiving 50 mg intravenous Pethidine) using the minimization method. The drugs were administered when there was at least a 4-cm cervical dilation. Maternal complications and infant’s 1 and 5-min the Apgar scores and ability to breastfeed were evaluated. Pain intensity measured by the Visual Analogue Scale (VAS) and compared using two-way repeated measures ANOVA before and 30 minutes, 1, 2, 3 and 4 hours after drug administration.
Results: There were no significant differences between the two groups in term of age, body mass index, and gestational age, and no significant difference in pain intensity in any groups among the time points. Maternal complications were significantly lower in the Paracetamol group than in the Pethidine group; however, the difference was statistically significant only in terms of nausea (P=0.04). Infants’ breastfeeding ability was significantly better in Paracetamol group than in the Pethidine group (P=0.04). The results of two-way ANOVA showed that the mean VAS score was not significantly different between the two groups.
Conclusion: Paracetamol can alleviate the first-stage labor pain similar to Pethidine, but with fewer maternal and neonatal complications.
Article Type : Research |
Subject:
Special
Received: 2021/02/28 | Accepted: 2021/10/16 | Published: 2022/07/1
Received: 2021/02/28 | Accepted: 2021/10/16 | Published: 2022/07/1
Send email to the article author
| Rights and permissions | |
 | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s).
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information
JHNM Office, Guilan University of Medical Sciences P.O.Box 41635-1873, Rasht, Iran
Journal Tel: +9813 33553202
Publisher Tel: +9821 453 55 555; +9821 453 55 000
Email: holisticnmj@gmail.com, nursjournal@gums.ac.ir
